Regional development made a dramatic comeback on the international development scene in 2008. It featured prominently in the flagship UN-Habitat publication, State of the World’s Cities 2008/20091 and equally emerged as a strong theme in the World Bank’s annual development report, World Development Report 2009: Reshaping Economic Geography,2 which reinforces the importance of space and place in effective development policy. In many respects the Provincial Government of the Western Cape (PGWC) has been ahead of the curve by embarking on a regional development policy dialogue in 2006, which culminated in the OECD Territorial Review3 (hereafter “the Review”) undertaken during 2007 and 2008 and published in late 2008. This paper argues that the foresight of the provincial government is to be commended and that the PGWC is now well placed to interrogate the recommendations and implications of the Review. Given the magnitude of economic, environmental and social challenges in the Western Cape which all require effective regional responses, a prioritisation of regional policy is imperative.